VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels.
Identifieur interne : 001632 ( Main/Exploration ); précédent : 001631; suivant : 001633VEGFR signaling during lymphatic vascular development: From progenitor cells to functional vessels.
Auteurs : Genevieve A. Secker [Australie] ; Natasha L. HarveySource :
- Developmental dynamics : an official publication of the American Association of Anatomists [ 1097-0177 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Cellules souches (cytologie), Cellules souches (métabolisme), Facteur de croissance endothéliale vasculaire de type C (métabolisme), Facteur de croissance endothéliale vasculaire de type D (métabolisme), Humains, Lymphangiogenèse (physiologie), Récepteur-2 au facteur croissance endothéliale vasculaire (métabolisme), Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme), Transduction du signal (physiologie), Vaisseaux lymphatiques (cytologie), Vaisseaux lymphatiques (embryologie).
- MESH :
- cytologie : Cellules souches, Vaisseaux lymphatiques.
- embryologie : Vaisseaux lymphatiques.
- métabolisme : Cellules souches, Facteur de croissance endothéliale vasculaire de type C, Facteur de croissance endothéliale vasculaire de type D, Récepteur-2 au facteur croissance endothéliale vasculaire, Récepteur-3 au facteur croissance endothéliale vasculaire.
- physiologie : Lymphangiogenèse, Transduction du signal.
- Animaux, Humains.
English descriptors
- KwdEn :
- Animals, Humans, Lymphangiogenesis (physiology), Lymphatic Vessels (cytology), Lymphatic Vessels (embryology), Signal Transduction (physiology), Stem Cells (cytology), Stem Cells (metabolism), Vascular Endothelial Growth Factor C (metabolism), Vascular Endothelial Growth Factor D (metabolism), Vascular Endothelial Growth Factor Receptor-2 (metabolism), Vascular Endothelial Growth Factor Receptor-3 (metabolism).
- MESH :
- chemical , metabolism : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor Receptor-3.
- cytology : Lymphatic Vessels, Stem Cells.
- embryology : Lymphatic Vessels.
- metabolism : Stem Cells.
- physiology : Lymphangiogenesis, Signal Transduction.
- Animals, Humans.
Abstract
Lymphatic vessels are an integral component of the cardiovascular system, serving important roles in fluid homeostasis, lipid absorption, and immune cell trafficking. Defining the mechanisms by which the lymphatic vasculature is constructed and remodeled into a functional vascular network not only provides answers to fascinating biological questions, but is fundamental to understanding how lymphatic vessel growth and development goes awry in human pathologies. While long recognized as dysfunctional in lymphedema and exploited as a route of tumor metastasis, recent work has highlighted important roles for lymphatic vessels in modulating immune responses, regulating salt-sensitive hypertension and important for lung inflation at birth. Substantial progress in our understanding of the signaling pathways important for development and morphogenesis of the lymphatic vasculature has been made in recent years. Here, we review advances in our knowledge of the best characterized of these signaling pathways, that involving the vascular endothelial growth factor (VEGF) family members VEGF-C and VEGF-D, together with their receptors VEGFR2 and VEGFR3. Recent work has defined multiple levels at which signal transduction by means of this key axis is regulated; these include control of ligand processing and bioavailability, modulation of receptor activation by interacting proteins, and regulation of receptor endocytosis and trafficking.
DOI: 10.1002/dvdy.24227
PubMed: 25399804
Affiliations:
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Le document en format XML
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Harvey</name></author></analytic><series><title level="j">Developmental dynamics : an official publication of the American Association of Anatomists</title><idno type="eISSN">1097-0177</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>Lymphangiogenesis (physiology)</term><term>Lymphatic Vessels (cytology)</term><term>Lymphatic Vessels (embryology)</term><term>Signal Transduction (physiology)</term><term>Stem Cells (cytology)</term><term>Stem Cells (metabolism)</term><term>Vascular Endothelial Growth Factor C (metabolism)</term><term>Vascular Endothelial Growth Factor D (metabolism)</term><term>Vascular Endothelial Growth Factor Receptor-2 (metabolism)</term><term>Vascular Endothelial Growth Factor Receptor-3 (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules souches (cytologie)</term><term>Cellules souches (métabolisme)</term><term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term><term>Facteur de croissance endothéliale vasculaire de type D (métabolisme)</term><term>Humains</term><term>Lymphangiogenèse (physiologie)</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire (métabolisme)</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire (métabolisme)</term><term>Transduction du signal (physiologie)</term><term>Vaisseaux lymphatiques (cytologie)</term><term>Vaisseaux lymphatiques (embryologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term><term>Vascular Endothelial Growth Factor D</term><term>Vascular Endothelial Growth Factor Receptor-2</term><term>Vascular Endothelial Growth Factor Receptor-3</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules souches</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lymphatic Vessels</term><term>Stem Cells</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Stem Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules souches</term><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Facteur de croissance endothéliale vasculaire de type D</term><term>Récepteur-2 au facteur croissance endothéliale vasculaire</term><term>Récepteur-3 au facteur croissance endothéliale vasculaire</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphangiogenèse</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphangiogenesis</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphatic vessels are an integral component of the cardiovascular system, serving important roles in fluid homeostasis, lipid absorption, and immune cell trafficking. Defining the mechanisms by which the lymphatic vasculature is constructed and remodeled into a functional vascular network not only provides answers to fascinating biological questions, but is fundamental to understanding how lymphatic vessel growth and development goes awry in human pathologies. While long recognized as dysfunctional in lymphedema and exploited as a route of tumor metastasis, recent work has highlighted important roles for lymphatic vessels in modulating immune responses, regulating salt-sensitive hypertension and important for lung inflation at birth. Substantial progress in our understanding of the signaling pathways important for development and morphogenesis of the lymphatic vasculature has been made in recent years. Here, we review advances in our knowledge of the best characterized of these signaling pathways, that involving the vascular endothelial growth factor (VEGF) family members VEGF-C and VEGF-D, together with their receptors VEGFR2 and VEGFR3. Recent work has defined multiple levels at which signal transduction by means of this key axis is regulated; these include control of ligand processing and bioavailability, modulation of receptor activation by interacting proteins, and regulation of receptor endocytosis and trafficking.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Harvey, Natasha L" sort="Harvey, Natasha L" uniqKey="Harvey N" first="Natasha L" last="Harvey">Natasha L. Harvey</name></noCountry><country name="Australie"><noRegion><name sortKey="Secker, Genevieve A" sort="Secker, Genevieve A" uniqKey="Secker G" first="Genevieve A" last="Secker">Genevieve A. Secker</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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